Dissecting the Quorum-Sensing Receptor LuxN
نویسنده
چکیده
Quorum sensing plays a key role in the behavior of many bacteria and is carried out by a wide diversity of secreted molecules and their receptors. In this issue, Swem et al. (2008) provide a detailed site-specific analysis of the functioning of the quorum-sensing receptor LuxN from Vibrio harveyi.
منابع مشابه
Deducing Receptor Signaling Parameters from In Vivo Analysis: LuxN/AI-1 Quorum Sensing in Vibrio harveyi
Quorum sensing, a process of bacterial cell-cell communication, relies on production, detection, and response to autoinducer signaling molecules. LuxN, a nine-transmembrane domain protein from Vibrio harveyi, is the founding example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers. We used mutagenesis and suppressor analyses to identify the AHL-binding domain of LuxN a...
متن کاملThe quorum-sensing hybrid histidine kinase LuxN of Vibrio harveyi contains a periplasmically located N terminus.
Hydropathy profile analyses of the amino acid sequence of the quorum-sensing hybrid histidine kinase LuxN of Vibrio harveyi predict a periplasmic location of the N terminus. To test this, two-hybrid proteins consisting of LuxN and an N-terminally fused maltose-binding protein with or without a leader sequence were analyzed with regard to the enzymatic activities of LuxN, protease accessibility,...
متن کاملActivity, Abundance, and Localization of Quorum Sensing Receptors in Vibrio harveyi
Quorum sensing (QS) is a process enabling a bacterial population to communicate via small molecules called autoinducers (AIs). This intercellular communication process allows single cells to synchronize their behavior within a population. The marine bacterium Vibrio harveyi ATCC BAA-1116 channels the information of three AI signals into one QS cascade. Three receptors perceive these AIs, the hy...
متن کاملSequence and function of LuxU: a two-component phosphorelay protein that regulates quorum sensing in Vibrio harveyi.
Vibrio harveyi regulates the expression of bioluminescence (lux) in response to cell density, a phenomenon known as quorum sensing. In V. harveyi, two independent quorum-sensing systems exist, and each produces, detects, and responds to a specific cell density-dependent autoinducer signal. The autoinducers are recognized by two-component hybrid sensor kinases called LuxN and LuxQ, and sensory i...
متن کاملA New Class of Quorum Quenching Molecules from Staphylococcus Species Affects Communication and Growth of Gram-Negative Bacteria
The knowledge that many pathogens rely on cell-to-cell communication mechanisms known as quorum sensing, opens a new disease control strategy: quorum quenching. Here we report on one of the rare examples where Gram-positive bacteria, the 'Staphylococcus intermedius group' of zoonotic pathogens, excrete two compounds in millimolar concentrations that suppress the quorum sensing signaling and inh...
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ورودعنوان ژورنال:
- Cell
دوره 134 شماره
صفحات -
تاریخ انتشار 2008